Ophthalmology

The effect of platelet-rich plasma and sodium alginate hydrogel on corneal wound healing after corneal alkali burns in rats with computer-assisted anterior segment optical coherence tomography image analysis

The effect of platelet-rich plasma and sodium alginate hydrogel on corneal wound healing after corneal alkali burns in rats with computer-assisted anterior segment optical coherence tomography image analysis

Highlights

  • The study evaluated healing effects of semisynthetic sodium alginate hydrogel alone and with PRP on corneal injuries in rats.
  • PRP and hydrogel together led to the greatest epithelial thickness and minimal necrosis, indicating improved healing.
  • Negative correlation found between tissue MMP-9 levels and corneal solidity, highlighting MMP-9's role in corneal healing.
  • Hydrogel alone didn't significantly improve wound healing, but with PRP, it accelerated epithelial closure and neovascularization.
  • New parameters for corneal wound healing assessment introduced via anterior segment optical coherence tomography processing.

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